肠道微生物组和代谢概况的特征在老年患者与肉类症
Jing Zhou1,2, Jiang Liu2, Qinqing Lin1,3
1Department of Geriatric Gastroenterology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Frontiers in pharmacology
|November 29, 2023
概括
改变的肠道细菌和代谢物与老年人肉症有关. 这项研究确定了特定的微生物和代谢特征,为肠道肌肉轴提供了洞察力,并为萨科佩尼亚提供了潜在的治疗点.
科学领域:
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
- 老年学是一门学科.
背景情况:
- 越来越多的证据将肠道微生物群与肉症的发展联系起来.
- 我们对肠道微生物组-新陈代谢在老年人中发生的相互作用的理解有限.
研究的目的:
- 为了研究肠道微生物群组成和老年人肉类的代谢概况之间的关系.
- 为了识别潜在的微生物和代谢生物标志物来诊断萨科佩尼亚.
主要方法:
- 16S rDNA测序了来自30名麻症和30名非麻症老年人的便样本.
- 基于液体染色学和质谱学 (LC-MS) 的非向代谢学分析.
- 临床指数,肠道微生物群和代谢物之间的相关性分析.
主要成果:
- 在肉患者中观察到29种细菌属和172种代谢物的显著变化.
- 像Blautia,Lachnospiraceae_unclassified和Subdoligranulum这样的品种显示出对萨尔科佩尼亚的诊断潜力.
- 对KEGG途径的分析表明, purin代谢,氨基酸代谢和丁酸盐代谢的差异.
结论:
- 肠道微生物群和代谢特征在老年人中发生显著变化.
- 特定的肠道细菌 (例如,Blautia) 和代谢物与肉类有关,它们支持肠-肌肉轴.
- 这些发现为探索新型致病机制和治疗萨尔科佩尼亚的治疗策略提供了基础.
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