生提取物对思普拉丁诱导的急性厌食症在老鼠的影响
Hyeonah Kim1, Keun-Tae Park1, Heejoon Jo1
1Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Frontiers in pharmacology
|November 29, 2023
概括
生提取物 (GE) 通过调节血清素通路来缓解西斯普拉丁诱导的厌食症. GE降低了血清激素水平,并降低了5-HT3A和5-HT4受体的调节,恢复了老鼠的食欲.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 西斯是一种重要的化疗药物,但它会引起严重的副作用,如急性厌食症.
- 了解西斯胺诱导的厌食症背后的机制对于开发支持性疗法至关重要.
研究的目的:
- 调查生提取物 (GE) 在减轻大鼠中西斯诱导的厌食症的疗效.
- 阐明涉及血清素 (5-HT) 和其受体的潜在神经化学机制.
主要方法:
- 鼠被用西斯丁和不同剂量的GE (100或500毫克/公斤) 治疗.
- 分析了血清激素水平,5-HT受体基因和结节腺中的蛋白质表达.
- 在HPLC中确定了GE中的活性化合物;用于确认机制的受体对抗剂.
主要成果:
- 转基因显著抵消了西斯胺诱导的食物摄入量和体重减少.
- 转基因的使用降低了血清激素水平的升高,并降低了5-HT3A和5-HT4受体表达的调节.
- [6]-醇和 [6]-shogaol,关键的GE成分,在组合时协同缓解了厌食症.
结论:
- 生提取物在治疗西斯普拉丁诱导的厌食症方面表现有前途.
- 治疗效果通过调节血清素5-HT3A和5-HT4受体通路进行调节.
关键词:
厌食症是一种厌食症.化疗诱导的厌食症引起的厌食症.西斯普拉丁 (cisplatin) 是一种制剂.生生是什么意思 生生是什么意思结节性质链 (Nodose Ganglion) 是一个结节性质链.血清胺 (serotonin) 是一种神经元.更多相关视频
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