童年逆境预测更强的月经前情绪恶化,压力评估和皮质醇下降在妇女与月经前失调障碍
Sibel Nayman1, Isabelle Florence Schricker1, Iris Reinhard2
1Research Group Longitudinal and Intervention Research, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Frontiers in endocrinology
|November 29, 2023
概括
在患有月经前失调障碍 (PMDD) 的女性中,童年逆境会加剧月经前情绪和压力. 较高的逆境与皮质醇模式的改变有关,这表明PMDD患者具有创伤史的不同神经内分泌亚型.
科学领域:
- 生殖精神病学是一种精神病学.
- 神经内分泌学神经内分泌学
- 心理创伤学 心理创伤学
背景情况:
- 月经前失调障碍 (PMDD) 与终身创伤有关.
- 童年逆境对PMDD的具体影响仍未得到充分探索.
- 本研究研究了童年逆境对PMDD症状周期性的影响.
研究的目的:
- 在PMDD中调查与月经周期相关的情绪变化,压力评估和皮质醇.
- 确定童年逆境对这些周期性模式的影响,控制最近的生活事件.
主要方法:
- 52名患有PMDD的妇女在四天内在卵泡和黄体阶段接受了门诊评估 (AA),五个月后重复.
- 收集的数据包括瞬间影响,压力评估和唾液皮质醇.
- 儿童时期的逆境和最近的压力生活事件通过问卷进行了评估.
主要成果:
- 情绪和压力评估显示了与周期相关的变化,随着时间的推移而减少;没有发现皮质醇循环性.
- 更高的童年逆境与更大的负面影响和压力评估相关,并且周期性地减少了积极的影响.
- 与较低逆境的女性不同的是,与卵泡阶段相比,具有较高童年逆境的女性表现出较低的晚期皮质醇,而不是较低逆境的女性.
结论:
- 在PMDD中,童年逆境独立地加剧了月经前情绪恶化和压力评估.
- 在高度不利的PMDD中观察到的皮质醇周期性可能表明与童年创伤相关的独特的神经内分泌亚型.
- 需要进一步的研究来探索这些潜在的PMDD亚型.
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