系统性免疫炎症指数和糖尿病之间的关联:来自NHANESES的基于人口的研究
Yiqi Nie1,2, Haiting Zhou3, Jing Wang3
1School of Medical Information Engineering, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China.
系统性免疫炎症指数 (SII) 与糖尿病风险有积极联系. 较高的SII水平与患糖尿病的机会增加了4%,独立于常见的风险因素.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 系统性免疫炎症指数 (SII) 是一个新兴的生物标志物.
- 以前的研究表明,SII和糖尿病之间存在潜在的关联.
研究的目的:
- 为了研究SII和糖尿病之间的关系,在一个庞大的,代表性的美国人口中.
- 为了确定SII是否是糖尿病的独立预测因素.
主要方法:
- 利用了2017-2020年国家健康和营养检查调查 (NHANES) 的数据.
- 包括7877名20岁以上的成年人,分析SII和糖尿病状况.
- 采用加权多变量回归,子组分析和平滑曲线拟合.
主要成果:
- 在SII和糖尿病之间发现了显著的积极关联 (OR = 1.04;95% CI: 1.02-1.06;p = 0.0006).
- 每个单位增加的SII与患糖尿病的可能性增加4%.
- 这种关联在各种人口统计和生活方式因素中保持一致.
结论:
- 升高的SII水平独立地与糖尿病风险增加有关.
- 进一步的前性研究是有必要的,以阐明潜在的机制.
- SII可以作为糖尿病风险评估的有价值指标.
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