在1型糖尿病的整个发展过程中,胰腺透和循环免疫细胞的足迹在1型糖尿病的发展过程中
Ylke Bruggeman1, Pieter-Jan Martens1, Gabriele Sassi1
1Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.
Frontiers in endocrinology
|November 29, 2023
概括
在NOD小鼠中研究了1型糖尿病 (T1D) 进展期间胰腺免疫细胞动态. 原始的T细胞流向胰腺,血液中的T细胞可能是治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 这是一种自身免疫力.
背景情况:
- 1型糖尿病 (T1D) 的特征是胰腺小岛 (胰岛炎) 的免疫细胞透,导致β细胞丧失.
- 了解T1D免疫细胞动态和表型对于开发新疗法和生物标志物至关重要.
研究的目的:
- 研究在非肥胖糖尿病 (NOD) 小鼠中T1D进展期间透胰腺,胰腺排水淋巴结 (PLN) 和外周血液的免疫细胞的动态变化.
- 为了比较不同组织中的免疫细胞概况,并将其与T1D发展相关联.
主要方法:
- 用多参数流细胞计分析免疫细胞种群.
- 从T1D进展的各个阶段的雌性和雄性NOD小鼠收集了样本.
- 单细胞RNA测序用于表征特定的T细胞子集.
主要成果:
- 早期T1D阶段显示,树突细胞和中性粒细胞涌入胰腺;中性粒细胞在症状前积累.
- 在疾病进展过程中,CD4+和CD8+T细胞从PLN迁移到胰腺,与胰岛炎和β细胞自身免疫性增加相关.
- 胰腺CD4+和CD8+T细胞转移到效应记忆表型,而PLNT细胞在很大程度上保持了天真;在外围血液中发现了一种新的前效应T细胞群.
结论:
- 在NOD小鼠的T1D病原体中,T细胞动态和功能状态的时间和组织依赖的变化至关重要.
- 周围血液中确定的预效因子T细胞代表了T1D的潜在新型治疗点.
- 这些发现需要在设计和解释T1D修饰疗法时加以考虑.
相关概念视频
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
1.3K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
Insulin and C-peptide are...
1.3K
Pathophysiology of Diabetes
950
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
950
Chronic Pancreatitis I: Introduction
90
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
90
Insulin Secretory Vesicles
5.0K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
5.0K
Diabetes Mellitus: Overview and Type I Subtype
2.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.7K


