标记性肥胖因素和良性前列腺增生之间的因果关系
Xuezhi Rao1,2, Zhijie Xu1,3, Jingchun Zhang4
1Beijing University of Chinese Medicine, Beijing, China.
Frontiers in endocrinology
|November 29, 2023
概括
像增加的基础代谢率 (BMR) 和尾肌瘦质量 (ALM) 这样的sarcopenic肥胖 (SO) 因素与更高的良性前列腺增生 (BPH) 风险有关. 这表明SO可能是防止BPH发展的保护因素.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 老年学是一门学科.
- 代谢健康 代谢健康
背景情况:
- 良性前列腺增生症 (BPH) 和肉骨肥胖症 (SO) 在老年男性中很普遍.
- 与SO相关的生活方式因素被确定为BPH的风险因素.
研究的目的:
- 为了研究 sarcopenic 肥胖因素和良性前列腺增生之间的潜在因果关系.
- 为了确定SO是否是BPH的风险或保护因素.
主要方法:
- 利用孟德尔的随机化分析与全基因组关联研究的总结数据.
- 采用逆方差加权方法来选择SO因子的仪器变量.
主要成果:
- 基础代谢率 (BMR) 的增加与BPH风险的增加有关 (OR = 1.248).
- 尾肌肉量 (ALM) 的增加也与较高的BPH风险有关 (OR = 1.126).
- 在无脂肪质量分布,肌肉质量分布和BPH之间没有发现遗传因果关系.
结论:
- 在BMR,ALM和BPH之间存在遗传因果关系.
- BMR和ALM被确定为BPH的危险因素.
- 降低的BMR和ALM表明SO的发病/进展,这表明SO作为BPH的保护因素.
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