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在患有童年开始的脑瘤的患者中,术后的下丘脑-垂体功能障碍和长期的激素替代治疗
Yuqi Miao1, Kaiyu Fan2, Xiaojiao Peng3
1Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Frontiers in endocrinology
|November 29, 2023
概括
手术后的下丘脑-垂体轴功能障碍在儿童瘤 (CP) 患者中很常见,需要长期的激素替代疗法以获得最佳的管理和生活质量.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经外科 神经外科
- 在瘤学瘤学.
背景情况:
- 瘤 (CP) 是一个常见的儿科脑瘤.
- 手术后的下丘脑-垂体轴功能障碍显著影响了CP幸存者的长期生活质量.
- 了解内分泌缺陷和激素替代对于管理儿童CP至关重要.
研究的目的:
- 为了评估在儿童瘤切除后的下丘脑-垂体功能障碍的长期影响.
- 评估这些患者的激素替代疗法的必要性和模式.
- 为了确定瘤复发率和相关的临床结果.
主要方法:
- 从大约200名患有童年开始的CP的患者的临床数据的回顾性分析.
- 包括在2018-2019年间接受细胞瘤切除的患者.
- 对内分泌功能,激素替代疗法和瘤复发的后续评估.
主要成果:
- 在手术后的第一周内,中央上腺功能衰竭 (56.2%) 和甲状腺功能低下症 (70.3%) 的高发病率.
- 85.5%的患者需要使用德斯莫普林素,94.4%的患者至少接受了一次激素替代治疗,74.7%的患者接受了三次或更多次激素替代治疗.
- 在随访期间观察到显著的矮身 (28.1%) 和肥胖 (54.4%) 率;瘤复发率为26.1%.
结论:
- 儿童瘤幸存者经常经历严重的长期内分泌功能障碍.
- 大多数患者需要多次激素替代,强调需要个性化管理.
- 精确的激素替代剂量对于改善儿科CP患者的治疗结果至关重要.
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