在POSEIDON组中,修改后的长性淋巴激素释放激素激素激素和非降低调节协议之间的比较:倾向性得分与回顾性队列研究相匹配
Chunyan Chen1, Xinliu Zeng1, Hanke Zhang1
1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in endocrinology
|November 29, 2023
概括
经过修改的长性淋巴激素释放激素激素激剂协议改善了POSEIDON患者的体外受精结果,与非降低调节协议相比,导致累积怀孕率更高.
科学领域:
- 生殖医学 生殖医学
- 在体外受精过程中受精.
- 辅助生殖技术 辅助生殖技术
背景情况:
- 试管受精 (IVF) 是治疗不孕症的关键方法,特别是在针对患者的策略中,包括个性化卵细胞数量 (POSEIDON) 群体.
- 为POSEIDON患者优化辅助生殖技术 (ART) 协议对于改善妊娠结果至关重要.
研究的目的:
- 在接受ART的POSEIDON患者中,为了比较经过修改的长性淋巴激素释放激素agonist (GnRH-a) 协议与非降低调节协议的有效性.
- 为了确定影响这特定患者群体怀孕结果的因素.
主要方法:
- 在2020年1月至2022年6月期间,对910名接受试管婴儿治疗的POSEIDON患者进行了倾向分数匹配 (PSM) 追溯分析.
- 患者被分为两组:修改长期GnRH-a协议 (I组) 和非降低调节协议 (II组).
- 基线特征,受控卵巢过度刺激和怀孕结果的比较,与累积怀孕率 (CPR) 分析的二进制逻辑回归.
主要成果:
- 在PSM之后,分析了174对患者. 第一个组的CPR (51.7%) 与第二组 (34.5%) 相比显著更高.
- 第一组的平均每日性腺激素 (Gn) 剂量较低,但使用Gn的持续时间较长.
- 与II组相比,在I组观察到显著更多的卵子被检索,二期转移 (MII) 卵子,正常受精,和分裂的胚胎.
结论:
- 在POSEIDON患者中,经过修改的长GnRH-a协议是试管婴儿或细胞内精子注射 (ICSI) 的最佳选择.
- 该方案在实现这一患者群体更高的怀孕率方面表现出卓越的有效性.
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