对比低剂量 (DART) 和增强低剂量德克萨米他治疗方案在早产婴儿与支气管肺功能障碍症
Heba Mohamed Al-Taweel1, Ismail Sabry Ismail Abdelhady2, Nasreen Irfan3
1Pharmacy Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.
Frontiers in pediatrics
|November 29, 2023
概括
在极低出生体重 (ELBW) 的支气管肺功能障碍症 (BPD) 婴儿中,低剂量和增强低剂量德克萨米他的比较显示,在输出成功方面没有显著差异. 考虑到剂量和通风的个性化治疗是成功输出管的关键.
科学领域:
- 新生儿科学 新生儿科学
- 儿科肺病学 儿科肺病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在极低出生体重 (ELBW) 患有支气管肺功能障碍 (BPD) 的婴儿中,优化德克萨米他松剂量用于输出管是具有挑战性的.
- 目前的证据并不能最终确定在这个脆弱人群中成功地进行脱口术的优越甲松治疗方案.
研究的目的:
- 为了比较低剂量 (DART) 与增强的低剂量德甲疗法的疗效.
- 为了评估在接受不同德克萨米他协议的BPD的ELBW婴儿中成功的输出率.
主要方法:
- 在妇女健康和研究中心 (WWRC) 从2015-2019年进行的回顾性队列研究.
- 包括接受德克萨米他用于BPD预防,治疗或输出管的ELBW婴儿.
- 在治疗后的不同时间点启动和完成成功的输出管的分析.
主要成果:
- 在任何评估时间点,在低剂量和增强低剂量德克萨米他组之间没有观察到输出成功的显著差异.
- 回归分析确定了基线FiO2,疗程持续时间和侵入性机械通风持续时间作为输出成功的负预测因素.
- 接收的每公斤剂量和累积剂量与成功的输出相对相关,而二次结果如死亡或BPD没有显著差异.
结论:
- 在低剂量和增强低剂量德克萨米他之间做出选择可能不会显著影响患有BPD的ELBW婴儿的输出成功.
- 个性化德克萨米他治疗,考虑到通风状态和治疗持续时间等因素至关重要.
- 可能需要进一步的研究来个性化德甲治疗策略,以获得ELBW婴儿的最佳结果.
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