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接种疫苗的方法儿科固体器官移植候选人和接收者

Carol M Kao¹, Marian G Michaels²

¹Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, United States.

Frontiers in pediatrics

|November 29, 2023

概括

固体器官移植 (SOT) 候选人和接受者面临感染的高风险. 本综述为儿童SOT患者接种疫苗提供专家指导,解决知识差距以改善结果.

科学领域:

免疫学免疫学免疫学
移植医学移植医学移植医学
疫苗学疫苗学疫苗学

背景情况:

固体器官移植 (SOT) 候选人和接受者对疫苗可预防的感染的脆弱性增加.
小儿SOT接种者面临着独特的挑战,因为初级免疫接种不完整,缺乏自然免疫力.
现有的SOT疫苗接种指导方针存在局限性,特别是在儿童群体中活疫苗的安全性和有效性数据方面.

研究的目的:

提供对接种疫苗的SOT候选人和接收者的实用,专家意见审查.
用可操作的见解来补充当前的疫苗接种指南.
突出儿科特定的知识差距和未来在SOT疫苗接种方面的研究方向.

主要方法:

本综述综合了当前的文献和专家的共识.
它侧重于移植后的时间和疫苗选择的实际考虑.
该审查涉及与免疫抑制和暴露风险相关的挑战.

主要成果:

疫苗接种对于预防SOT患者的发病率和死亡率至关重要.
需要个性化的疫苗接种策略,考虑到患者特定的因素.
在小儿SOT接种者中使用活疫苗需要仔细考虑,因为数据有限.

结论:

优化疫苗接种计划对于保护SOT候选人和接种者至关重要.
需要进一步的研究来解决疫苗的安全性和有效性,特别是活疫苗,在小儿SOT接受者.
专家意见和量身定制的方法可以改善疫苗覆盖率和这一弱势群体的结果.

关键词:

免疫接种免疫接种移植前评估移植前评估实体器官移植实体器官移植疫苗可以预防的感染.疫苗,疫苗,疫苗的使用情况.

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