基于电位传导的基于纸质的分析装置,用于灵敏地确定巴比他
Abdulrahman A Almehizia1, Ahmed M Naglah1, Mashael G Alanazi2
1Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457,Riyadh 11451, Saudi Arabia.
ACS omega
|November 29, 2023
概括
一种基于纸张的新型传感器可以检测到关键的抗药物芬巴比他 (PBAR),为治疗监测提供了一个低成本的便携式解决方案. 这种一次性设备在药品样本中提供了快速而准确的PBAR检测.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- (PBAR) 是世卫组织推用于治疗和的重要巴比酸药物,特别是在儿童中使用.
- 准确和可访问的PBAR检测方法对于有效的治疗至关重要,特别是在资源有限的环境中.
- 现有的分析方法可能是复杂的,昂贵的,不适合 point-of-care 应用.
研究的目的:
- 开发和描述一款基于纸张的新型分析装置,用于简单,经济实惠和便携式检测PBAR.
- 创建一个一次性传感器,使用集成到纸质基板上的固态离子选择电极 (ISE) 来进行PBAR量化.
- 评估传感器的性能,包括检测极限,响应时间,选择性和精度,用于现实世界制药样本分析.
主要方法:
- 在非导电纸质基板上制造用于PBAR的固态离子选择电极 (ISE),使用碳纳米管墨水进行导电.
- 开发一种聚合物膜,将新的pyrido-tetrapeptide和pyrido-hexapeptide衍生物作为选择性PBAR离子识别的离子体.
- 基于纸张的传感器的优化和表征,包括电位测量测量,使用修改分离溶液方法的选择性研究,以及对HPLC的验证.
主要成果:
- 基于纸质的分析装置证明了Nernstian对PBAR离子的反应在1.0 × 10−6到1.0 × 10−3M的线性范围内,检测极限为5.0 × 10−7M.
- 传感器表现出快速响应时间 (不到5秒) 和PBAR离子检测的良好精度.
- 开发的传感器成功地在真实药品样本中检测到微量PBAR,结果与HPLC参考方法相似.
结论:
- 这种基于纸制造的分析装置提供了一种简单,经济高效,便携和一次性检测 (PBAR) 的方法.
- 这项技术对治疗点PBAR的确定具有很大的潜力,特别是当与电位计检测相结合时,这便于治疗.
- 集成在纸质传感器中的新离子体提供了选择性和敏感的PBAR检测,解决了医学诊断的关键需求.
更多相关视频
13:42Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
Published on: September 19, 2017
11.8K
11:17Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
Published on: February 10, 2014
11.8K
相关概念视频
01:15Potentiometry: Membrane Electrodes
587
Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...
587
01:06Potentiometry: Overview
2.1K
Potentiometry is an analytical technique that measures the potential difference between two electrodes in an electrochemical cell without drawing any significant current that could alter the solution's composition. This method employs an indicator electrode, which exchanges electrons with the analyte solution, and a reference electrode with a constant potential. Each electrode is immersed in a solution comprised of two half-cells. In a conventional setup, the reference electrode serves as...
2.1K
01:19Potentiometry: Types of Electrodes
673
Reference electrodes serve as a stable reference point for potentiometric measurements, while indicator and working electrodes react to variations in the composition of a solution.
The Standard Hydrogen Electrode (SHE) is a widely used reference electrode that maintains zero potential across all temperatures. However, its need for a continuous hydrogen gas supply renders it impractical for everyday use.
An alternative to SHE is the Saturated Calomel Electrode (SCE). This electrode features an...
The Standard Hydrogen Electrode (SHE) is a widely used reference electrode that maintains zero potential across all temperatures. However, its need for a continuous hydrogen gas supply renders it impractical for everyday use.
An alternative to SHE is the Saturated Calomel Electrode (SCE). This electrode features an...
673
01:17Controlled-Potential Coulometry: Electrolytic Methods
175
Controlled-potential coulometry, also known as potentiostatic coulometry, employs a three-electrode system in which the working electrode's potential is precisely regulated using a potentiostat. Platinum working electrodes are utilized for positive potentials, while mercury pool electrodes are favored for extremely negative potentials. The platinum counter electrode is separated from the analyte using a membrane or salt bridge to avoid interference in the analysis.
The chosen potential...
The chosen potential...
175
01:15High-Performance Liquid Chromatography: Types of Detectors
583
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
583