便秘和中风之间的关联基于NHANES和门德尔随机化研究
Wenjuan Du1, Shengkai Yang1, Hai Zhou1
1Binhai County People's Hospital, Yancheng, China.
Frontiers in neuroscience
|November 29, 2023
概括
这项研究发现,便秘与大动脉动脉样硬化 (LAS),一种类型的中风的更高风险有关. 然而,门德尔的随机分析没有显示便秘和整体中风风险之间的因果关系.
科学领域:
- 心血管流行病学心血管流行病学
- 胃肠病学 胃肠病学
- 神经学 神经学
背景情况:
- 横截面研究表明,便秘和中风风险增加之间存在联系.
- 了解便秘和中风之间的因果关系对于公共卫生至关重要.
- 调查潜在的遗传倾向可以阐明潜在的机制.
研究的目的:
- 通过双向孟德尔随机化 (MR) 分析,研究便秘和中风之间的假定因果关系.
- 通过逻辑回归来评估便秘和中风患病率之间的关联.
- 检查便秘和中风亚型之间的因果关系.
主要方法:
- 使用全基因组关联研究统计数据的双向孟德尔随机化 (MR) 分析.
- 逻辑回归模型用于评估横截面关联.
- 使用逆方差加权 (IVW) 方法进行初级分析,并得到灵敏度分析 (加权中位数,加权模式,简单模式,MR-Egger回归) 的支持.
- 测试异质性和性 (科克兰的Q,MR-Egger拦截,MR-PRESSO,MR-Steiger) 的测试.
主要成果:
- 逻辑回归表明便秘与中风风险增加有关 (OR=1.46,p=0.042).
- 核磁共振分析显示,便秘和大动脉动脉样硬化 (LAS) (IVW OR=1.5,p=0.019) 之间存在显著的关联.
- 在MR分析中,没有发现便秘与整体中风风险或其亚型之间的显著因果关系. 反向MR分析也显示没有显著的因果关系.
结论:
- 虽然横截面数据表明便秘增加了中风风险,但这项MR研究发现了与大动脉动脉硬化 (LAS) 的积极相关性.
- 该研究没有通过MR分析确定便秘和整体中风或其亚型之间的因果关系.
- 灵敏度分析表明没有显著的水平变,影响因果估计.
更多相关视频
相关概念视频
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K
Confounding in Epidemiological Studies
170
Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This...
170
Cause and Effect
10.9K
While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
10.9K
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
86
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
86
Drugs for Treatment of Constipation-Predominant IBS
179
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
179


