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瓦卡林通过降低NOX4衍生的ROS来缓解西斯普拉丁诱导的急性损伤

Tingni Wu¹, Wenxian Ma¹, Weili Lu¹

¹Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, 230032, China.

|November 29, 2023

概括

瓦卡林是一种黄类糖化物,通过抑制尼古丁胺氨酸二核酸盐 (NADPH) 氧化酶4 (NOX4) 的作用,保护免受西斯普拉丁诱导的急性损伤 (AKI). 这项研究证明了vaccarin的存在.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
药理学药理学是指药理学的学科.
生物化学生物化学

背景情况:

西斯是固体瘤的关键化疗剂.
西斯普拉丁诱导的急性损伤 (AKI) 是一个重大的临床挑战.
开发防护剂来防止西斯的毒性是非常重要的.

研究的目的:

为了研究瓦卡林的保护作用,一个黄类糖化物,对西斯普拉丁诱导的AKI.
阐明瓦卡林脏保护作用的潜在机制.

主要方法:

在C57BL/6J小鼠和人类-2 (HK-2) 细胞中使用西斯胺诱导的AKI模型.
评估功能标志物 (BUN,肌) 和组织学变化 (PAS染色).
测量脏白金积累 (ICP-MS),氧化应激 (ROS),NOX4表达,亡,亡和炎症标志物.

主要成果:

在接受西斯丁治疗的小鼠中,Vaccarin的使用显著降低了BUN,肌素水平和PAS得分.
瓦卡林减轻了氧化应激和NOX4表达在体内和体外.
瓦卡林抑制了与RIPK1相关的亡,亡 (切割-卡斯帕酶3) 和炎症 (NLRP3,p-P65).

结论:

瓦卡林显示出显著的脏保护作用,防止西斯普拉丁诱导的AKI.
保护机制包括抑制NOX4介导的氧化应激,亡,亡和炎症.
瓦卡林代表了一种潜在的治疗药物,可以预防西斯的毒性.

关键词:

急性损伤是什么?急性损伤是什么?西斯普拉丁 (Cisplatin) 是一种炎症炎症是一种炎症.在NOX4中,NOX4是接种疫苗中的疫苗.

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