患有慢性并发症的2型糖尿病患者的低循环素水平:一个元分析
Qiaoyu Hou1,2, Rongjing Song1, Xuecheng Zhao3
1Department of Pharmacy, Peking University People's Hospital, Beijing, 100044, China.
Heliyon
|November 29, 2023
概括
在患有2型糖尿病和慢性并发症的患者中,虹膜素水平显著降低. 较低的伊丽素与糖尿病并发症严重程度的增加有关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢性疾病是一种代谢性疾病.
- 生物标志物 生物标志物
背景情况:
- 2型糖尿病 (T2DM) 是一种复杂的代谢障碍.
- 慢性并发症显著影响T2DM患者的结果.
- 虹膜素是一种肌酸蛋白,在能量恒温和新陈代谢调节中起作用.
研究的目的:
- 调查T2DM患者和没有慢性并发症的循环素水平.
- 为了比较T2DM患者,T2DM患有并发症的患者和健康对照者之间的虹膜素水平.
- 探索虹膜素水平与糖尿病并发症严重程度之间的关系.
主要方法:
- 一个全面的已发表研究的元分析.
- 在主要数据库 (PubMed,Cochrane,Embase等) 进行文献搜索. 截至 2022 年 12 月.
- 随机效应模型和标准平均差 (SMD) 用于聚合分析.
主要成果:
- 在分析中包括了42项研究.
- 与没有慢性并发症的T2DM患者相比,与没有慢性并发症的T2DM患者 (SMD: -1.43) 观察到循环素水平显著降低.
- 与健康对照组相比,患有并发症的T2DM患者的虹膜素水平也较低 (SMD: -2.40).
- 随着糖尿病脏病和视网膜病变等并发症的恶化,观察到虹膜素的进一步下降.
结论:
- 患有慢性并发症的T2DM患者表现出较低的循环素水平.
- 虹膜素水平与T2DM慢性并发症的严重程度有负相关性.
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