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长非编码RNA在与年龄相关的黄斑退化中的作用和机制

Rong Zhang¹, Lin Wang¹, Yang Li²

¹Department of Ophthalmology, Shanxi Eye Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi 030002, China.

|November 29, 2023

概括

长非编码RNAs (lncRNAs) 在与年龄相关的黄斑变性 (AMD) 病变发生过程中至关重要. 失调的lncRNAs通过影响关键细胞过程来影响AMD进展,提供潜在的治疗点和生物标志物.

科学领域:

眼科医生眼科眼科
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

与年龄相关的黄斑变性 (AMD) 是老年人视力丧失的主要原因.
目前用于排泄性AMD的治疗方法对许多患者无效,并且对于非排泄性AMD没有批准的策略.
驱动AMD的精确机制,包括德鲁森形成和黄斑缩,仍然在很大程度上是未知的.

研究的目的:

审查长非编码RNAs (lncRNAs) 在与年龄相关的黄斑变性 (AMD) 病原发生中的关键作用.
探索失调的lncRNA及其向分子对AMD进展有所贡献的机制.
突出 lncRNAs 作为 AMD 的生物标志物和治疗点的潜力.

主要方法:

文献综述侧重于AMD中失调的lncRNAs的功能.
对涉及lncRNAs在AMD病变发生过程中的分子机制的分析.
检查有关细胞类型中细胞过程的lncRNA调节.

主要成果:

lncRNAs在AMD的发展和进展中发挥着重要作用.
调节失调的lncRNAs调节视网膜关键细胞中的亡,上皮-介质细胞过渡 (EMT),脱差和氧化应激.
特定的lncRNAs分子向影响了与AMD相关的细胞事件.

结论:

lncRNAs是AMD发病过程中不可或缺的组成部分,影响关键细胞功能.
lncRNAs显示出作为AMD诊断和预后的有价值生物标志物的潜力.
对lncRNAs进行进一步的研究是有必要的,以开发新的AMD治疗策略.

关键词:

与年龄相关的黄斑变性.生物标志物生物标志物长的非编码RNA是什么?斑点退化症斑点退化症黄斑疾病是什么? 黄斑疾病是什么?

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