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新的与烧死相关的lncRNA和ceRNA预测骨髓瘤的预后,并表明免疫微环境的特征

Mingyi Yang¹, Haishi Zheng¹, Yani Su¹

¹Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China.

|November 29, 2023

概括

这项研究确定了与灭相关的基因和长非编码RNAs作为骨髓瘤 (OS) 的关键预后生物标志物. 一个新的风险评分预测了患者的结果和免疫微环境特征,有助于诊断和治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

骨肉瘤 (OS) 的预后和免疫微环境特征需要进一步调查,以改善治疗策略.
作为一种被编程的细胞死亡途径的灭,涉及特定的基因 (PRGs) 和长非编码RNA (PRLncs),可能会影响癌症的进展.

研究的目的:

为了识别与骨质肉瘤预后和免疫微环境相关的亡相关生物标志物.
建立基于与热致死相关的长非编码RNA (PRLncs) 的骨髓瘤预后模型.

主要方法:

利用癌症基因组图谱 (TCGA) 数据库分析了88名骨髓瘤患者的转录组和临床数据.
预后模型是使用灭相关基因 (PRGs) 和长非编码RNAs (PRLncs) 构建的.
分析了免疫细胞透,瘤微环境和与火死相关的竞争性内源性RNA (PRceRNA) 网络.

主要成果:

五个PRG (CHMP4C,BAK1,GSDMA,CASP1,CASP6) 和七个PRLncs被确定为OS的预后标志物.
开发了一个风险预后模型 (PRLncs-score),证明了OS患者的独立预后价值.
低PRLncs-score与转移的减少,更好的存活率,免疫细胞透的增加和免疫活动的增加有关.

结论:

已识别的PRG和PRLnc作为骨髓瘤的有价值的预后指标.
PRLncs-score有效地预测了OS预后和免疫微环境状态.
这些发现为改善早期诊断和开发针对骨髓瘤的向免疫疗法提供了基础.

关键词:

免疫系统的免疫系统.骨质肉瘤骨质肉瘤是什么热灭菌的发生.瘤微环境是一个微环境.ceRNARNA是什么意思在ncRNA中,我们可以

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