类黄酸和粘附分子:在动脉样硬化管理中的潜在作用
Farnaz Ebrahimi1,2, Mohammad Mahdi Ghazimoradi3, Ghizal Fatima4
1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan, Iran.
Heliyon
|November 29, 2023
概括
类黄酸在通过减少关键粘附分子来控制动脉样硬化方面表现有前途. 建议对患者进行进一步的研究,以确认这些抗炎和抗氧化作用.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 动脉样硬化是一种与氧化应激相关的慢性炎症性疾病,导致显著的发病率和死亡率.
- 像ICAM-1,VCAM-1,P-selectin和E-selectin这样的粘附分子是动脉样硬化发展的关键贡献者.
- 使用富含抗氧化剂和抗炎化合物功能性食物的饮食干预措施越来越感兴趣.
研究的目的:
- 审查关于类黄在治疗动脉样硬化中的作用的现有证据.
- 专注于类黄对动脉样硬化所涉及的粘附分子的影响.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行了全面的文献搜索.
- 搜索包括从最初到2023年1月的粘附分子和黄类药物相关的术语.
- 分析了动脉样硬化的临床前模型的证据.
主要成果:
- 类黄类化合物,包括素,素,素,素和素,对粘附分子 (ICAM-1,VCAM-1,E-selectin,P-selectin) 产生调节作用.
- 类黄类药物的使用使慢性炎症标志物 (介质蛋白,TNF-α,NF-κB) 和氧化应激 (SOD,谷氨) 的正常化.
- 临床前研究强烈支持类黄在动脉样硬化模型中的有益作用.
结论:
- 根据临床前发现,类黄在动脉样硬化背景下调节粘附分子方面发挥着重要作用.
- 类水果需要在涉及动脉样硬化患者的临床试验中进行进一步的研究,以评估其降低粘附分子的潜力.
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