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肠道性酸酶改善了肠道的透性,并缓解了热中风引起的多个器官功能障碍
Zhen Luo1,2, Zeze Wang1,2, Ping Li1,2
1Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, Chongqing, China.
Heliyon
|November 29, 2023
概括
肠道性酸酶 (IAP) 通过加强肠道屏障和减少炎症来防止热中风. 这项研究表明,IAP通过保持肠道完整性,在热中风模型中提高了生存率.
科学领域:
- 生理学 生理学 生理学
- 胃肠病学 胃肠病学
- 生物化学 生物化学
背景情况:
- 热中风 (HS) 是一种严重的疾病,与肠道功能障碍,炎症和器官损伤有关.
- 肠道性酸酶 (IAP) 在肠道平衡和屏障功能中发挥作用.
- IAP在热中风中的保护作用尚未完全理解.
研究的目的:
- 为了研究IAP对热中风的保护作用.
- 确定IAP是否可以保持肠道屏障的完整性并改善肠道透性.
主要方法:
- 雄性C57BL/6小鼠被暴露在热中,直到核心温度达到42.7°C.
- 暴露于热量的小鼠通过测量器接受了盐水,载体或300 IU IAP.
- 对照小鼠没有接触到热量,并接受了盐水.
主要成果:
- IAP治疗降低了内毒素,FD4和D-乳酸盐水平.
- IAP通过增加紧密结合蛋白来改善肠道屏障的完整性.
- IAP减轻了器官损伤,减少了炎症性细胞因子,并提高了生存率.
结论:
- IAP增强了肠道屏障的功能,并降低了透性.
- IAP可以减轻热中风的全身炎症和器官损伤.
- IAP显示出作为热中风和其他有肠道透性障碍的疾病的治疗剂的潜力.
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