用于口服的glibenclamideproniosomes的配方:制药和药理动力学评估
Doaa Alshora1, Mohamed Ibrahim1, Nouf Alanazi1
1Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
概括
格利本克拉米德proniosomes显著改善了口服抗糖尿病药物的溶解和生物可用性. 这种增强的配方导致血糖水平降低73%,没有肝脏损伤,性能优于纯药物.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 药理学 药理学是指药理学的学科.
背景情况:
- 基胺 (GB) 是一种口服的硫基尿素,对于管理II型糖尿病至关重要.
- 低水溶性限制了glibenclamide的口服生物可用性和治疗功效.
- 基因组提供了一种潜在的策略,以克服溶解性挑战并增强药物输送.
研究的目的:
- 通过亲子体配方增强glibenclamide (GB) 的溶解和药理作用.
- 为了描述准备好的 Glibenclamide proniosomes 并评估它们的体外和体内表现.
- 在糖尿病模型中评估glibenclamideproniosomes的稳定性和治疗疗效.
主要方法:
- 用糖糖作为载体的泥方法制备了glibenclamide的proniosomal配方.
- 描述包括粒子大小,泽塔潜力,捕获效率,粉末流动特性和体外溶解研究.
- 在动物模型中,通过在治疗前和治疗后测量空腹血糖水平来评估药理效果.
主要成果:
- 亲子体配方表现出良好的稳定性,颗粒大小在190~1369nm之间,泽塔电位在-20mV以上.
- 与纯药物相比,所有glibenclamide的proniosome配方都显示出明显更高的溶解率.
- 亲组治疗导致禁食血糖水平降低73%,明显高于纯药物观察到的17.6%的降低,没有肝脏损伤的迹象.
结论:
- 亲子体配方有效地提高了glibenclamide的可溶性和溶解率.
- 与纯药物相比,glibenclamide proniosomes在降低血糖水平方面表现出优越的治疗疗效.
- 格利本克拉米德 (glibenclamide) 的亲子体配方代表了一种有前途,稳定和有效的药物输送系统,用于II型糖尿病的管理.
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