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早期2型糖尿病的并发症和治疗方法
Fahimeh Soheilipour1, Naghmeh Abbasi Kasbi2, Mahshid Imankhan3
1Minimally Invasive Surgery Research Center, Aliasghar Children Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
International journal of endocrinology and metabolism
|November 29, 2023
概括
全球范围内,2型糖尿病 (T2DM) 正在增加,特别是在年轻人中. 早期发病的T2DM患者面临更具侵略性的血管并发症,需要联合治疗以有效控制血糖.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 儿科糖尿病 儿科糖尿病
背景情况:
- 全球2型糖尿病 (T2DM) 的发病率在过去30年中急剧增加,影响所有年龄组,包括儿童和青少年.
- 早期发病的T2DM与更具侵略性的临床过程有关,这给治疗带来了挑战.
- 青春期的胰岛素耐药性,以及遗传和表观遗传因素,有助于早期T2DM的增加.
研究的目的:
- 审查T2DM早期发作的微型和宏观血管并发症.
- 检查T2DM早期发作的当前治疗策略.
- 突出儿童T2DM日益增长的患病率和挑战.
主要方法:
- 在PubMed数据库上进行了文献搜索.
- 包括2018年1月至2023年1月间发表的英语原始文章.
- 专注于研究早期T2DM,其并发症和治疗方法.
主要成果:
- 血管并发症 (白血病,高血压,心血管疾病,视网膜病变) 在早期发病的T2DM中比1型糖尿病更为普遍.
- 与晚期T2DM相比,早期T2DM显示血管并发症的几率比较高.
- 单独使用甲胺治疗不足以维持持续的血糖控制;早期的联合治疗通常是必要的. 已批准的药物包括甲型胺,胰岛素和GLP-1激动剂.
结论:
- 早期发病的T2DM频率的增加是一个重大问题.
- 在T2DM早期发作的血管并发症是积极的,难以管理.
- 进一步的临床试验对于开发新疗法和评估长期结果至关重要.
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