在过敏性鼻炎的老年患者中,对HDM进行过敏原免疫治疗后的长期益处
Andrzej Bożek1, Agnieszka Bogacz-Piaseczyńska1, Martyna Miodońska1
1Clinical Department of Internal Medicine, Dermatology and Allergology in Zabrze, Medical University of Silesia in Katowice, Poland.
Postepy dermatologii i alergologii
|November 29, 2023
概括
过敏原免疫疗法 (AIT) 为患有过敏性鼻炎和室内灰尘虫过敏的老年人提供持续的缓解. 这项为期7年的研究证实了AIT对老年人的长期益处.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 老年医学 老年医学
背景情况:
- 过敏原免疫疗法 (AIT) 对过敏性鼻炎有效,但对老年人的长期益处尚未明确.
- 室内灰尘 (HDM) 是常见的过敏原,可引发过敏性鼻炎.
研究的目的:
- 为了评估AIT在60岁以上的患有HDM过敏的患者的长期有效性.
- 为了评估持续的临床效应和血清学标记,治疗后长达7年.
主要方法:
- 一项长达7年的观察性研究,涉及60岁以上的患有HDM过敏的患者.
- 与安慰剂组相比,语言下 (SLIT) 和注射 (SCIT) AIT与安慰剂组进行了比较.
- 监测平均调整的症状评分 (AAdSS) 和血清特异性IgG4 (sIgG4).
主要成果:
- 在HDM-AIT (SLIT和SCIT) 3年后,与基线和安慰剂相比,观察到AAdSS显著减少 (p <0.05).
- 与安慰剂相比,AIT后7年发现了临床症状下降的持续趋势.
- 在所有接受过脱敏治疗的患者中,血清sIgG4的存在始终如一.
结论:
- 过敏原免疫疗法对因家尘引起的过敏性鼻炎的老年人具有显著和持续的临床益处.
- 在老年人群中,AIT是治疗过敏性鼻炎的可行和有益的治疗选择.
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