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使用LSIM-CT对肺输液的量化与CTEPD患者的肺血液动力学相关

Tomohiro Yamaguchi¹, Shoichi Ehara², Hisako Yoshida³

¹Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.

Frontiers in cardiovascular medicine

|November 29, 2023

概括

使用肺减去映射CT的降低肺 perfusion area (DPA) 比率可以估计慢性血栓栓塞性肺病 (CTEPD) 患者的肺动脉平均压力. 这种成像参数与血液动力学状况有显著的相关性,有助于评估CTEPD.

科学领域:

放射学放射学是指放射学
心脏病学心脏病学
肺部医学肺部医学

背景情况:

慢性血栓栓塞性肺病 (CTEPD) 涉及到肺部输血不良.
肺部减去映射 (LSIM) -CT可视化了这种输血不良.
在CTEPD中LSIM成像和血液动力学参数之间的关联尚未得到充分确立.

研究的目的:

在CTEPD患者中调查LSIM图像参数与平均肺动脉压 (mPAP) 之间的关联.
用LSIM参数验证肺血管阻力,右心房压,心脏指数和运动能力之间的关系.

主要方法:

对30名CTEPD患者进行前性观察性研究.
计算了肺 perfusion 区域 (DPA) 的比率 (0-10,0-15,0-20,0-30 HU) 与肺总体积相比.
使用斯皮尔曼等级相关性与mPAP相关联的DPA比率.

主要成果:

0-10 HU的DPA比率显示出与mPAP的最强相关性 (ρ=0.440,P=0.015).
这种DPA比率也与肺血管阻力有显著的相关性 (ρ=0.445,P=0.015).
8.5%的DPA比率是预测mPAP≥30 mmHg (AUC=0.773) 的最佳截止值.

结论:

从LSIM-CT获得的DPA比率是估计CTEPD血液动力状况的潜在有价值的工具.
LSIM-CT提供一种非侵入性方法来评估疾病严重程度和指导CTEPD的管理.

关键词:

慢性血栓栓塞性肺病慢性血栓塞性肺病慢性血栓栓塞性肺高血压慢性血栓塞性肺高血压肺部减去映射计算机断层扫描计算机断层扫描肺部血液动力学肺部血液动力学肺高血压是一种肺高血压.测量肺 perfusion 的量化情况.

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