严重的Candida感染在COVID-19的危急病患者中
Despoina Koulenti1,2, Marios Karvouniaris3, Elisabeth Paramythiotou1
1Second Critical Care Department, Attikon University Hospital, Athens, Greece.
Journal of intensive medicine
|November 29, 2023
概括
侵袭性真菌感染,特别是候选血症,在重症COVID-19患者中增加. 这些感染恶化了结果,并显示出日益增长的耐药性,需要仔细诊断和管理.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 菌类学 菌类学是指菌类学.
背景情况:
- 在COVID-19大流行期间,重症患者的细菌和真菌共同感染率有所上升.
- кандидемия作为一种频繁的侵入性真菌联合感染而出现,在COVID-19病例中经常出现延迟发病.
- 在COVID-19患者中,候选血症的危险因素包括侵入性手术和疾病严重程度,与非COVID-19患者不同.
研究的目的:
- 审查和讨论在重症COVID-19患者中由Candida物种引起的侵入性真菌感染的诊断和管理.
- 突出COVID-19的背景下,与候选血症相关的发病率增加和风险因素变化.
- 为应对新出现的抗真菌耐药性挑战,包括耐可纳和耐多药性Candida auris.
主要方法:
- 这项研究是一个叙事性审查.
- 收集了有关COVID-19患者侵入性真菌感染的信息,并进行了批判性讨论.
- 专注于诊断,管理和候选血病的结果.
主要成果:
- 侵袭性Candida共感染,特别是候选血症,在重症COVID-19患者中增加.
- 在COVID-19患者中,Candida感染与侵入性手术和疾病严重程度有关.
- 报告说,抗可纳菌株和抗多药性Candida auris菌株的增加,对患者的发病率和死亡率产生了负面影响.
结论:
- 侵入性Candida联合感染显著增加了重症COVID-19患者的发病率和死亡率.
- 抗真菌耐药性的出现构成重大威胁,需要谨慎监测和适应治疗策略.
- 有效的诊断和管理方案对于改善这种脆弱患者群体的治疗结果至关重要.
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