精液蛋白质组学揭示了COVID-19复苏后生育相关蛋白质的变化
Ankita Dash1, Akanksha Salkar1, Mehar Un Nissa1
1Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
Frontiers in physiology
|November 29, 2023
概括
COVID-19感染影响男性生殖健康,甚至在康复后影响精子质量和功能. 这些影响不管SARS-CoV-2的变种或疫苗接种情况如何,都会持续存在,这凸显了长期的生育问题.
科学领域:
- 生殖生物学 生殖生物学
- 传染性疾病 传染性疾病
- 蛋白质组学是指蛋白质组学.
背景情况:
- COVID-19的恢复与男性生殖功能下降有关.
- 新出现的SARS-CoV-2变种给全球健康带来了持续的挑战.
- COVID-19变种对男性复苏后生殖健康的影响尚不清楚.
研究的目的:
- 研究COVID-19对男性生殖健康的长期影响.
- 在COVID-19后恢复的男性中分析精液蛋白质谱.
- 为了比较不同SARS-CoV-2变体 (Alpha和Delta) 对男性生育能力的影响.
主要方法:
- 在精液样本上使用基于质谱的蛋白质组学.
- 从不同波 (阿尔法和三角形流行) 和对照的COVID-19康复男性中收集了样本.
- 进行了统计分析 (单向ANOVA) 和途径丰富分析.
主要成果:
- 与对照组相比,在COVID-19康复的男性中,69种蛋白质显著失调.
- 在康复的患者中,精子数量,形态和运动性发生了变化.
- 与精子生成,免疫反应和精子功能相关的关键途径受到调节.
结论:
- 在康复后,COVID-19对男性生殖系统有持续的有害影响.
- 这些影响不论是SARS-CoV-2变种或疫苗接种情况都会观察到.
- 这项研究提供了受COVID-19影响的精液蛋白的全面蛋白质学景观.
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