昼夜节律对人类大脑中NAD和其他代谢物的影响
Bernard Cuenoud1,2, Zhiwei Huang3,4, Mickael Hartweg5
1Research and Clinical Development, Nestlé Health Science, Epalinges, Switzerland.
Frontiers in physiology
|November 29, 2023
概括
循环节律 (CR) 并没有显著改变人类脑中的尼古丁胺胺氨酸二核酸 (NAD) 水平. 然而,CR确实影响了牛水平,冒险行为和皮质醇,证实了不同的生理状态.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 代谢研究的研究.
背景情况:
- 尼古丁胺氨酸二核酸 (NAD) 对于模型生物体中的大脑主昼夜钟 (上性核,SCN) 至关重要.
- NAD代谢受到昼夜周期的严格调节,但其在人类大脑中的作用尚不清楚.
- 了解昼夜节律对人类大脑代谢的影响是必不可少的.
研究的目的:
- 为了研究昼夜节律 (CR) 对尼古丁胺氨酸二核酸 (NAD) 和人类其他大脑代谢物的影响.
- 评估日间变化是否影响脑后脑部区域的NAD水平.
- 为了将生理和行为变化与昼夜状态相关联.
主要方法:
- 在25名健康参与者身上进行了一项高场磁共振光谱 (MRS) 研究.
- 在早晨和下午状态期间,在头大脑中测量了NAD和其他代谢物水平.
- 评估了唾液皮质醇和冒险倾向,以确认昼夜变化.
主要成果:
- 循环节律 (CR) 并没有显著影响脑中的NAD水平.
- 氨酸水平受到CR的显著影响,而乳酸盐和其他代谢物没有显著变化.
- CR影响了唾液皮质醇水平和冒险行为,验证了不同的生理状态.
结论:
- 在研究的条件下,人类脑的NAD水平并没有受到昼夜节律的显著调节.
- 氨酸可能是一个比NAD在这个地区更敏感的标记者昼夜影响大脑新陈代谢比NAD.
- 在其他大脑区域的进一步研究可能会揭示对NAD和牛代谢的更强的昼夜效应.
关键词:
这就是MRS MRS.在这里,我们可以看到NAD,NAD,NAD.大脑大脑大脑的大脑大脑昼夜节律 昼夜节律乳酸乳酸是一种乳酸.代谢 代谢 代谢 代谢氧化氧化还原技术是什么taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine taurine 是一种类型的氨基酸相关概念视频
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