在印度尼西亚一家三级医院,为功能临床化学参数建立参考间隔
P Liana1,2, O Olivia3, S Fertilita4
1Department of Clinical Pathology, Faculty of Medicine, Universitas Sriwijaya, Mohammad Hoesin General Hospital, Palembang, Indonesia.
Archives of Razi Institute
|November 29, 2023
概括
这项研究确定了印尼成年人尿酸,尿素和肌素的新性别特定参考间隔. 这些特定于人群的功能测试值提高了帕伦班的诊断准确性.
科学领域:
- 临床化学 临床化学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物统计学 生物统计学
背景情况:
- 参考间隔对于解释临床化学值和指导医疗决策至关重要.
- 现有的RI因种族,性别和年龄等人口因素以及分析方法而有很大差异.
- 确定特定人群的RI对于准确的临床解释至关重要.
研究的目的:
- 确定和建立关键功能测试在印度尼西亚目标人口的参考值.
- 在研究队伍中调查功能测试参数的性别特异性差异.
- 为尿酸,尿素和肌素提供最新的局部参考间隔.
主要方法:
- 采用了横截面的观察分析研究设计.
- 分析了Palembang的Mohammad Hoesin医院医疗专业人员的医疗检查数据.
- 使用2.5和97.5百分位数计算参考间隔,并使用统计测试 (科尔莫戈罗夫-斯米尔诺夫,t测试,曼-惠特尼) 进行数据分析和组比较.
主要成果:
- 在尿酸,尿素和肌素水平上观察到基于性别的显著差异 (P<0.001).
- 建立了性别特定的参考间隔:尿酸 (男性: 230.78-526.99 μmol/L,女性: 179.03-415.17 μmol/L);尿素 (男性: 2.22-4.99 mmol/L,女性: 1.78-4.28 mmol/L);肌 (男性: 61.01-106.99 μmol/L,女性: 40.67-77.81 μmol/L).
结论:
- 这项研究成功地定义了印度尼西亚帕伦班的成年人群中尿酸,尿素和肌素的性别特定参考间隔.
- 预计这些人群特异性RI的实施将提高实验室测试和临床决策的精度和可靠性.
- 局部化RI对于在不同人群中准确的健康评估和患者管理至关重要.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
99
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
99
01:23Renal Clearance
985
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
985
01:11Renal Failure: Dose Adjustments
95
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
95
01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
135
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
135
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
146
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
146
01:29Renal Regulation of Acid-Base Balance
468
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
468