在伊拉克不孕男性的样本中,介质素17和生长差异化因子9的影响
D S Al-Rubaye1, H Mohammed Hamza1, Q Ahmed Al-Khafaji2
1Department of Biotechnology, College of Science, Baghdad University, Baghdad, Iraq.
Archives of Razi Institute
|November 29, 2023
概括
与对照组相比,男性不孕症标志物介质素-17 (IL-17) 和生长分化因子9 (GDF9) 在阿佐精子和小精子精子组中升高. 这些发现可能有助于了解男性不孕不育的原因.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 男人不孕症研究研究
- 生殖免疫学 生殖免疫学
背景情况:
- 不孕症影响10-15%的夫妇,男性因素有很大贡献.
- 了解男性不孕症背后的分子机制对于诊断和治疗至关重要.
- 介素-17 (IL-17) 和生长分化因子9 (GDF9) 是参与生殖过程的细胞因子.
研究的目的:
- 在不育的男性中研究IL-17和GDF9的血水平之间的关联.
- 为了比较在不育男性中IL-17和GDF9的水平,阿佐精和奥利戈精与正常精对照.
主要方法:
- 该研究包括93名参与者:18名患有亚精子,65名患有小精子和10名对照.
- 用标准化试验测量IL-17和GDF9的血水平.
- 统计分析涉及单向ANOVA和最不显著差异后期试验.
主要成果:
- 与对照组 (5,392±1,731 ng/l) 相比,亚精子 (21,317±3,605 ng/l) 和小精子 (15,101±2,416 ng/l) 组的平均IL-17血水平显著更高.
- 与对照组 (12.807±2.170 ng/l) 相比,阿佐精子 (3.299±1.051 ng/l) 和小精子精子 (6.2603±2.621 ng/l) 组的平均血GDF9水平显著更高.
- R平方值表示回归模型解释的方差比例.
结论:
- 血IL-17和GDF9水平升高与男性不孕症有关,特别是在阿佐精子症和橄精子症中.
- 这些细胞因子可以作为男性不孕不育的潜在生物标志物.
- 对于非阻塞性精/精,如果发现有活力的精子,丸精子提取后的细胞内精子注射是推的方法.
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