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在COVID-19的住院患者中使用抗生素:香港的一项基于人口的研究

Joseph Edgar Blais^1,2, Weixin Zhang¹, Yun Lin¹

¹World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administration Region, China.

Antimicrobial stewardship & healthcare epidemiology : ASHE

|November 29, 2023

概括

针对COVID-19住院患者的抗菌药物处方在各个流行病浪潮中存在显著差异. 老年,严重疾病和疫苗接种状况等因素影响了处方率,强调了需要谨慎管理抗生素的必要性.

科学领域:

传染性疾病传染性疾病
公共卫生公共卫生
药理学药理学是指药理学的学科.

背景情况:

香港面临多次严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 波,其中包括一个显著的Omicron波.
在整个大流行期间,针对2019年新冠病毒病 (COVID-19) 住院患者的抗菌处方模式存在有限的研究.

研究的目的:

描述COVID-19期间住院患者抗菌药物处方趋势.
在住院COVID-19患者中确定与抗菌药物处方相关的因素.

主要方法:

对香港COVID-19住院患者电子健康记录的回顾性分析 (2020年1月至2022年9月).
评估抗菌药物的流行率和发病率 (DOT/1000 PD).
多变量后勤回归用于探索患者特征,疾病严重程度和抗菌处方之间的关联.

主要成果:

在65810名COVID-19住院患者中,超过54%接受了抗菌药物 (550.5DOT/1000PD).
处方率波动,在第4波 (28.0%) 中最低,在第5波 (64.6%) 早期达到顶峰.
高龄,严重/致命的疾病和较少的COVID-19疫苗剂量与抗菌剂的使用增加有关.

结论:

针对COVID-19住院患者的抗菌药物处方在整个流行病期间不断发展.
处方模式与患者人口统计,疾病严重程度,疫苗接种状态和流行病波动力学有关.
这些发现强调了抗生素管理在管理COVID-19住院治疗中的重要性.

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