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甲状腺参数与中性粒细胞/淋巴细胞和血小板/淋巴细胞的比率之间的相关性甲状腺二型糖尿病患者

Hui Chen¹, Jun-Qiang Ju¹, Xiao-Wu Qian¹

¹Department of Geriatrics, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou, Jiangsu, People's Republic of China.

Diabetes, metabolic syndrome and obesity : targets and therapy

|November 29, 2023

概括

在2型糖尿病中,甲状腺功能发生改变,TSH水平较高,FT3/FT4水平较低. 这些甲状腺变化与糖尿病患者的NLR和PLR等炎症标志物相关.

科学领域:

内分泌学在内分泌学.
代谢障碍代谢障碍代谢障碍
临床化学临床化学

背景情况:

2型糖尿病 (T2DM) 是一种与代谢失调相关的全球健康问题.
炎症在T2DM的发病和进展中起着重要作用.
甲状腺功能障碍可以影响代谢过程,但其与T2DM炎症的关系需要进一步调查.

研究的目的:

为了研究甲状腺参数:甲状腺刺激激素 (TSH),自由三甲状腺素 (FT3) 和自由甲状腺素 (FT4).
检查这些甲状腺激素和炎症指标之间的关系,特别是中性粒细胞/淋巴细胞比率 (NLR) 和血小板/淋巴细胞比率 (PLR).
分析在被诊断患有2型糖尿病 (T2DM) 的人群中这些关联.

主要方法:

一项涉及672名T2DM患者和336名年龄和性别匹配的健康对照的比较研究.
甲状腺激素 (TSH,FT3,FT4) 和炎症标志物 (WBC,中性粒细胞,NLR,PLR) 的实验室分析.
统计分析,包括相关性和多重阶段回归,以确定关系和贡献因素.

主要成果:

与对照组相比,T2DM患者表现出炎症标志物 (WBC,中性粒细胞,NLR,PLR) 的升高.
在T2DM组中,TSH水平较高,FT3/FT4水平较低.
TSH与NLR/PLR正相关,而FT3/FT4与NLR/PLR负相关. 性别,年龄,NLR,PLR,LDL,HbA1c和TC是影响甲状腺参数的重要因素.

结论:

患有T2DM的优甲状腺体个体表现出异常的甲状腺激素代谢.
这种异常与炎症活性升高和糖脂代谢受损有关.
甲状腺的参数与T2DM的炎症标志物和代谢因素有显著的关联.

关键词:

中性粒细胞/淋巴细胞的比例.血小板/淋巴细胞的比例甲状腺功能甲状腺功能甲状腺的参数甲状腺的参数 2型糖尿病是什么?

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