最近被诊断为2型糖尿病的患者的腹部脂肪分布和血清尿酸之间的相关性
Hong-Ping Wang1, Yuan-Ying Xu1, Bi-Lin Xu1
1Department of Endocrinology, Putuo Hospital, Shanghai University of Traditonal Chinese Medicine, Shanghai, 200333, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|November 29, 2023
概括
腹部内脏脂肪与新型2型糖尿病患者的血清尿酸水平较高有关. 越来越多的内脏脂肪独立地预测高尿血和胰岛素抵抗风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 2型糖尿病是一个日益严重的全球健康问题.
- 高尿路血症越来越多地被认为是代谢风险因素.
- 在新诊断的2型糖尿病中,腹部脂肪分布和血清尿酸之间的关系需要进一步阐明.
研究的目的:
- 为了研究腹部脂肪分布和血清尿酸 (SUA) 度之间的关联.
- 确定腹部脂肪是否是该人群中高尿素血症的独立风险因素.
- 评估腹部脂肪对高尿血和胰岛素抵抗的预测价值.
主要方法:
- 一项涉及364名最近被诊断患有2型糖尿病的人的横截面研究.
- 评估腹部脂肪分布 (皮下和内脏),葡萄糖代谢标志物和脂质概况.
- 参与者被分为正常的SUA控制组和高尿血症组.
主要成果:
- 超尿血症组的腹部内脏脂肪面积 (VFA),皮下脂肪面积 (SFA),BMI显著增加,以及较差的葡萄糖/脂质概况.
- 后勤回归显示,每增加10cm2的VFA,就增加了24%的高尿血风险.
- 在ROC曲线分析中,VFA被认为是超尿血和胰岛素抵抗的最有效预测因子.
结论:
- 在新诊断的2型糖尿病中,腹部内脏脂肪和SUA水平之间存在强烈的相关性.
- 腹部内脏脂肪是高尿血的独立危险因素.
- 腹部内脏脂肪作为评估高尿血和预测胰岛素耐药性的有价值指标.
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