绝经前期和绝经后期初级甲状腺功能障碍症之间的表现和结果的差异 印度妇女:单一中心经验
Aasim N Maldar1, Nishitkumar F Shah1, Phulrenu H Chauhan1
1Department of Endocrinology, P. D. Hinduja Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
Journal of mid-life health
|November 29, 2023
概括
与绝经后妇女相比,患有原发性甲状腺功能障碍症 (PHPT) 的绝经前妇女出现了更多的症状和更高的血清水平. 尽管疾病更严重,但PHPT的手术结果在绝经前和绝经后的妇女之间是相似的.
科学领域:
- 内分泌学 在内分泌学.
- 手术研究的研究.
- 妇女健康 妇女健康
背景情况:
- 初级副甲状腺症 (PHPT) 的特点是过度的副甲状腺激素 (PTH) 生产,导致高血症.
- 更年期状态影响内分泌疾病的表现和严重程度.
研究的目的:
- 为了比较诊断PHPT的绝经前和绝经后妇女之间的临床,实验室和手术变量.
- 根据更年期状态确定疾病表现和治疗结果的差异.
主要方法:
- 在2011年至2020年间接受手术的130名女性PHPT患者的回顾性分析.
- 排除患有家族性PHPT和二次性副甲状腺炎症的患者.
主要成果:
- 绝经前妇女患有症状性PHPT (84.5%vs68.1%) 和结石 (34.5%vs18.1%) 的患病率较高.
- 在绝经前妇女中,性酸酶的升高更为常见 (37.9%对20.8%),平均血清和PTH水平较高.
- 手术后饥饿骨综合征在绝经前妇女中发生的频率更高 (15.5%对1.4%).
结论:
- 虽然大多数PHPT患者是绝经后的,但绝经前的妇女表现出更严重的症状和实验室发现.
- 尽管呈现有差异,但PHPT的手术结果和局部化率并没有因更年期状态而有显著差异.
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