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完整的基因组测序和比较基因组分析三只驴Streptococcus equi亚种. 均等的隔离物质

Yuwei Zhang¹, FenFen Lv¹, Yan Su¹

¹Department of Microbiology and Immunology, College of Veterinary Medicine, Xinjiang Agricultural University, Ürümqi, Xinjiang, China.

Frontiers in microbiology

|November 29, 2023

概括

菌株之间的遗传交换影响驴杀病原体进化. 这项研究揭示了驴子分离体中的基因组适应,为杀流行病学提供了洞察力.

科学领域:

兽医微生物学兽医微生物学
进行比较基因组学.
马类传染病马类传染病

背景情况:

被Streptococcus equi亚种 equi (S. equi) 引起的杀,是马的高度传染性呼吸道疾病.
S. equi是从动物感染病原体Streptococcus equi亚种zooepidemicus (S. zooepidemicus) 进化而来的,但遗传交换机制尚不清楚.

研究的目的:

为了研究S. equi从驴子中分离出来的基因组进化.
将驴子S. equi基因组与马类S. equi菌株进行比较,以确定影响它们适应的遗传事件.

主要方法:

三个S. equi驴子分离体 (HTP133,HTP232,HT1112) 的全基因组测序.
与马类S. equi 4047菌株进行比较的基因组分析.
鉴定基因组重组,反转和移动遗传元素.

主要成果:

驴和马的S. equi菌株具有高度的核心基因组相似性,但表现出结构上的差异,如重排和反转.
基因组岛屿和prophages显著影响了S. equi菌株的病原性和遗传多样性.
特定的隔离物显示增强了殖民,抗菌素耐药性,生物膜形成或氨酸酶获取.

结论:

比较基因组学揭示了S. equi菌株之间的遗传交换推动了驴类特定S. equi基因组的进化.
这些发现为了解S. equi的流行病学和马匹中杀疫情提供了关键的遗传见解.

关键词:

Streptococcus equi 是一个有毒的细菌.抗微生物耐药性抗微生物耐药性进行比较的基因组学.驴子,驴子,驴子的意思是什么意思毒性毒性是一种毒性.整个基因组的测序.

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