在克罗恩病和Hidradenitis suppurativa中对饮食肠道微生物组进行比较分析
Peter Cronin1,2, Siobhan McCarthy2,3, Cian Hurley4
1Department of Biological Science, University of Limerick, Limerick, Ireland.
Frontiers in microbiology
|November 29, 2023
概括
百分之四十的辅助性胆固醇炎 (HS) 患者与克罗恩病 (CD) 患者共享肠道微生物群概况,其特点是有害细菌. 这一发现表明便微生物群分析可以确定HS患者患有CD的风险较高.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 皮肤病学 皮肤病学
背景情况:
- 补腺炎 (HS) 和克罗恩病 (CD) 是具有共同临床和分子途径的慢性炎症状况.
- 西方饮食与炎症性疾病的增加有关,但肠道微生物群和HS和CD的饮食相互作用仍未得到充分研究.
研究的目的:
- 为了比较HS,CD和健康对照患者的便微生物群组成和习惯饮食.
- 为了确定HS和CD之间的潜在微生物或饮食联系.
主要方法:
- 使用16S rRNA基因安普利康序列的便微生物群分析.
- 对习惯性食物摄入的饮食评估.
- 测量炎症标志物,包括Gas6和IL-12.
主要成果:
- 脊髓炎患者食用西方饮食,与CD患者相似,与对照群不同.
- 40%的HS患者表现出类似于CD患者的微生物群概况,具有丰富的致病性和耗尽的有益基因.
- 剩余的60%的HS患者具有与对照组相似的正常微生物群. 抗生素使用与微生物群差异相关. 抗炎性Gas6较低,而促炎性IL-12与CD类HS微生物群中的有益细菌减少相关.
结论:
- 一个HS患者的子集与CD患者共享了异生物性肠道微生物群.
- 便微生物群的组成可以作为生物标志物来预测HS患者的CD风险.
- 饮食模式,特别是西方饮食,在这些炎症条件下可能会影响肠道微生物群.
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