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结核菌菌的耐药菌株:细胞外的形状和与宿主之间的相互作用

Alyssa Schami^1,2, M Nurul Islam³, John T Belisle³

¹Population Health Program, Texas Biomedical Research Institute, San Antonio, TX, United States.

Frontiers in cellular and infection microbiology

|November 29, 2023

概括

耐药的结核菌菌菌株 (M.tb) 是一个日益严重的威胁. 本综述探讨了M.tb细胞包膜的变化如何促进耐药性和影响结核病感染结果.

科学领域:

微生物学与传染病的研究
药物耐药性机制药物耐药性机制
结核病的发病因子

背景情况:

越来越多的耐药 (DR) 结核菌菌菌株 (M.tb) 蔓延,包括多药耐药 (MDR) 和广泛耐药 (XDR) 形式,构成了重大的全球卫生挑战.
COVID-19大流行对DR结核病 (DR-TB) 的发展和传播的影响在很大程度上是未知的.
虽然M.tb细胞包裹得到了充分的研究,但与药物耐药性获得相关的其组成变化尚未完全理解.

研究的目的:

为了回顾M.tb细胞外的复杂性.
调查与药物耐药性相关的M.tb的结构和生化变化.
描述M.tb耐药性对感染结果的影响,包括健康状况,持久性细菌和亚临床结核病.

主要方法:

对M.tb细胞外组成和耐药性现有研究的文献综述.
对DR-M.tb菌株结构和生化变化的最新研究进行分析.
综合关于耐药性对M.tb感染动态和临床表现的影响的研究结果.

主要成果:

作为对抗药物的反应,M.tb细胞外经历了显著的结构和生化修饰.
这些变化对于了解DR-M.tb菌株如何逃避当前抗结核药物至关重要.
在M.tb中耐药性影响细菌健康,持续细胞的形成和亚临床结核病感染的发展.

结论:

了解DR菌株中M.tb细胞包膜的适应性对于开发有效的治疗策略至关重要.
了解这些变化可以为设计新型抗结核病药物提供信息,以对抗难以治疗的菌株.
需要进一步的研究,以充分阐明M.tb耐药性,细胞包膜改变和临床结果之间的联系.

关键词:

M.tb-主机交互的作用.结核病菌菌菌的结核病菌的结核病菌.细胞外脂质细胞外脂质药物耐药性耐药性药物耐药性结核病是一种肺结核病.

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