口腔 - 肠道 - 循环轴:从恒常状态到结肠癌
Sofia C Tortora1, Maria Gonzalez Agurto2, Laura A Martello1
1Department of Medicine and Division of Gastroenterology & Hepatology, SUNY Downstate Health Sciences University, Brooklyn, NY, United States.
Frontiers in cellular and infection microbiology
|November 29, 2023
概括
人类微生物群影响免疫平衡. 本综述探讨了口腔-肠-循环轴及其在健康和结肠癌中的作用,强调了微生物相互作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 人类微生物群在宿主健康中起着至关重要的作用,特别是免疫恒温.
- 微生物失衡 (失生症) 与各种疾病有关.
- 口腔和肠道是与疾病有关的主要微生物群落的所在地.
研究的目的:
- 审查口腔-肠-循环轴的细菌成分.
- 阐明轴在健康和疾病中的作用.
- 专注于轴在结肠癌中的参与.
主要方法:
- 综合文献综述. 这是一个全面的文献综述.
- 对微生物相互作用的现有研究进行分析.
- 专注于口腔 - 肠道 - 循环轴内的细菌成分.
主要成果:
- 口腔 - 肠道 - 循环轴涉及免疫细胞,炎症因素,循环细菌和微生物代谢物之间的复杂相互作用.
- 双向通信影响口腔和肠道微生物群的稳态.
- 这个轴内的失生症与疾病的发病有关.
结论:
- 口腔-肠-循环轴是理解微生物相关疾病的关键框架.
- 了解这一轴为结肠癌等疾病提供了潜在的治疗点.
- 对这一轴的细菌动力学的进一步研究是有必要的.
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