老龄化和性别差异大脑体积和大脑血流量大脑血流量
Hiroto Kawano1, Shigeki Yamada2,3, Yoshiyuki Watanabe4
1Department of Neurosurgery, Shiga University of Medical Science, Shiga, Japan.
Aging and disease
|November 29, 2023
概括
大脑衰老显示大脑血流 (CBF) 的区域体积变化和性别差异. 皮层灰质体积与CBF有很强的相关性,女性的流量更高,这可能解释了脑血管疾病中的性别差异.
科学领域:
- 神经成像和神经科学 神经成像和神经科学
- 脑血管生理学 脑血管生理学
- 衰老研究研究 衰老研究
背景情况:
- 衰老影响大脑结构和功能,包括区域大脑体积和脑血流 (CBF).
- 了解CBF中与年龄相关的变化和性别差异对于识别脑血管疾病风险至关重要.
研究的目的:
- 为了研究区域大脑体积比率和CBF如何随着年龄的增长而变化.
- 在这些与年龄相关的变化中识别潜在的性别差异.
- 在健康个体中探索大脑体积比率和CBF之间的关系.
主要方法:
- 在129名健康志愿者 (年龄22-92岁) 中利用3D T1加权MRI,飞行时间MRI血管造影和4D流动MRI.
- 将大脑自动细分成21个子区域.
- 在16个主要的内动脉中测量CBF,并分析了与威利斯圆周周的大脑体积比率的关系.
主要成果:
- 最强的关联是皮质灰质体积比率与内动脉总流量 (r=0.425) 之间.
- 与男性相比,女性在威利斯圆周的平均流入和流出量显著增加.
- 在左皮层灰质体积比率和左前后脑动脉流量 (r=0.486) 之间发现了更强的相关性.
结论:
- 皮层灰质体积是CBF的重要预测因素,观察到显著的性别差异.
- 年轻女性具有较大的皮质灰质体积的CBF较高,可能会导致他们患动脉瘤,下关节出血和偏头痛的风险增加.
- 这些发现突显了大脑结构,血液流动,衰老和脑血管健康背景下的性别之间的复杂关系.
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