临床试验前和临床试验的结合研究:海藻消费减少了与衰老相关的肌肉损失!
Jimin Hyun1, Sang Yeoup Lee2,3, Bomi Ryu4
1Department of Marine Life Sciences, Jeju National University, Jeju, Republic of Korea.
Aging and disease
|November 29, 2023
概括
棕藻石 (Ishige okamurae) 补充剂改善了人类和小鼠的肌肉强度和质量,提供了一种潜在的营养策略来应对与年龄相关的肌肉损失 (sarcopenia). 这项研究突出了IOIO.
科学领域:
- 老年学和营养科学研究
- 海洋生物技术和营养保健品
背景情况:
- 肉症,与年龄相关的肌肉损失,缺乏有效的治疗方法,药物选择具有安全性和有效性的限制.
- 棕色藻类 Ishige okamurae (IO) 和其化合物在改善老年雌性小鼠的肉症方面表现有前途.
- 需要进一步的人类研究来验证海藻在打击与年龄相关的肌肉衰退中的作用.
研究的目的:
- 为了研究 Ishige okamurae (IO) 补充剂对人类肉症和肌肉力量的影响.
- 在小鼠模型中评估IO对衰老和肌肉衰竭相关标记物的影响.
主要方法:
- 一个为期12周的临床试验,80名参与者 (平均年龄~63岁) 接受500mg/kgIO或安慰剂.
- 评估生命体征,肌肉强度 (下肢四头肌) 和毒性参数.
- 在12个月大的雄性小鼠中,口服IO (50,100,200毫克/公斤) 持续6周,评估握力,身体组成,血清标志物和肌肉分子变化.
主要成果:
- 在接受IO的人类试验参与者中没有观察到显著的毒性或不良影响.
- 与对照组相比,IO组显示下肢四头肌肌肉强度显著增加 (p=0.002).
- 在小鼠中,IO的使用改善了握力,瘦身量,肌肉再生标记物和线粒体功能,同时降低了蛋白质分解.
结论:
- 这项研究提供了第一个证据,表明棕藻IO消费与老年人肌肉强度的改善之间存在积极联系.
- IO补充剂有效地抵消与年龄相关的肌肉损耗,并保持肌肉质量,表明其作为对抗肉类的营养策略的潜力.
- 在人体临床试验和动物模型中,IO在对抗与年龄相关的肌肉衰退方面都显示出显著的益处.
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