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用于描述α-Synuclein聚合物的不同多态形式的连接体配置

Timothy S Chisholm1, Christopher A Hunter1

  • 1Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

Journal of the American Chemical Society
|November 29, 2023
PubMed
概括

在神经退行性疾病中常见的粉状纤维具有独特的结构. 这项研究引入了一种联结方法来分析α-synuclein (αSyn) 纤维的形态,有助于疾病诊断.

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
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