相关实验视频

Updated: Jul 9, 2025

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

在妊娠糖尿病中,L-ergothioneine减少了线粒体驱动的NLRP3激活

Colm J McElwain¹, Andrea Musumeci¹, Samprikta Manna²

¹Department of Pharmacology and Therapeutics, Western Gateway Building, University College Cork, Cork, Ireland.

Journal of reproductive immunology

|November 29, 2023

概括

孕期糖尿病 (GDM) 中的孕产妇高血糖症通过线粒体功能障碍和NLRP3炎症酶激活增加了胎盘炎症. 抗氧化剂L-ergothioneine可能提供一种治疗方法.

科学领域:

线粒体生物学线粒体生物学
免疫学免疫学免疫学
生殖医学是一种生殖医学.

背景情况:

母亲高血糖症显著影响胎盘代谢和线粒体功能.
NLRP3炎症酶对线粒体功能障碍信号作出反应.
孕期糖尿病 (GDM) 涉及可能由线粒体功能障碍引起的胎盘炎症.

研究的目的:

调查线粒体功能障碍是否驱动NLRP3炎症酶激活和GDM中的炎症.
探索抗氧化剂在缓解GDM相关的胎盘炎症方面的治疗潜力.

主要方法:

从具有正常葡萄糖耐受性 (NGT) 和GDM的妇女收集的胎盘组织.
量化无细胞线粒体DNA (cf-mtDNA) 副本数.
描述了巨细胞群 (M1-类和M2-类) 和测量了炎症标记物 (NLRP3,ASC,caspase-1,IL-1β,IL-18).
用L-ergothioneine (抗氧化剂) 和MCC950 (NLRP3抑制剂) 治疗的胎盘扩张物.

主要成果:

在GDM胎盘中,cf-mtDNA复制数显著增加,巨细胞中线粒体超氧化物产量增加.
在GDM怀孕中,胎盘IL-18水平显著升高.
用MCC950或L-ergothioneine治疗减弱了胎盘IL-18.8的增加.

结论:

胎盘炎症在GDM中加剧,可能由巨细胞中的线粒体超氧化物生产启动,并由NLRP3炎症酶介导.
线粒体抗氧化剂L-ergothioneine在改善GDM中NLRP3诱导的胎盘炎症方面显示出潜在的治疗疗效.

关键词:

抗氧化剂是一种抗氧化剂.孕期糖尿病是一种糖尿病.炎症炎症是一种炎症.线粒体中的线粒体.在NLRP3中,NLRP3是NLRP3中的一个.胎盘胎盘胎盘胎盘

更多相关视频

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

相关概念视频

Diabetes Mellitus: Type 2 and Gestational

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...

Glucagon-like Receptor Agonists

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...