合成,表征和发现多种抗癌机制的dibutyltin复合物基于salen-like连接体的复合物
Wei Tian1, Wen Zhong1, Zengyan Yang1
1Guangxi International Zhuang Medicine Hospital, Nanning 530201, China; Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530201, China; Guangxi Institute of Ethnic Medicine, Nanning 530201, China.
Journal of inorganic biochemistry
|November 29, 2023
概括
新型双酸复合物显示出强大的抗癌活性. 复合S03通过多种途径有效诱导癌细胞死亡,提供了对抗药物耐药性的新策略.
科学领域:
- 有机金属化学 有机金属化学
- 药用化学 医学化学
- 癌症生物学 癌症生物学
背景情况:
- 有机蛋白化合物正在探索其治疗潜力.
- 盐类联体提供了多功能协调化学.
- 开发具有多种机制的新型抗癌药物至关重要.
研究的目的:
- 为了合成和表征新的双酸复合物与salen-like连接体.
- 评估这些复合物的体外抗癌活性.
- 阐明有前途的化合物的作用机制.
主要方法:
- 使用光谱 (UV-Vis,IR,NMR) 和分析技术 (MS,X射线晶体学,TGA) 合成和表征双乙复合物 (S01-S03).
- 通过细胞活力测试 (IC50测定) 进行体外抗癌活性评估.
- 涉及活性氧物种 (ROS) 激活,诱导亡,细胞周期分析和途径分析 (线粒体,ER压力,DNA损伤) 的机制研究.
主要成果:
- 新型双酸复合物 (S01-S03) 已成功合成和表征.
- 复合S03在体外对CAL-27细胞系 (IC50 = 1.5 ± 0.2μM) 具有显著的抗癌活性.
- 复杂的S03通过激活ROS诱导癌细胞死亡,触发细胞亡,导致G2/M细胞循环停止,并参与线粒体,ER压力和DNA损伤途径.
结论:
- 双丁复合物,特别是S03,显示出有前途的抗癌性质.
- 复杂的S03的多目标机制提供了一个潜在的策略来克服化学抵抗.
- 这些发现为开发基于有机素的抗癌疗法提供了洞察力.
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