相关实验视频

Updated: Jul 9, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

机械壁面应力和壁面剪切应力与非化冠状动脉段的动脉样硬化发展有关

Aikaterini Tziotziou¹, Eline Hartman², Suze-Anne Korteland¹

¹Department of Biomedical Engineering, Erasmus Medical Center, Rotterdam, the Netherlands.

Atherosclerosis

|November 29, 2023

概括

机械壁应力 (MWS) 和壁剪应力 (WSS) 显著影响动脉样硬化发展. 更高的MWS促进血管生长,而高WSS和低MWS的结合增加了冠状动脉中富含脂质的死核大小.

科学领域:

心血管研究的心血管研究.
生物医学工程生物医学工程
病理生理学病理生理学

背景情况:

动脉样硬化受当地生物力学因素的影响.
墙壁剪切应力 (WSS) 的作用被研究,但机械墙壁应力 (MWS) 的影响被理解得更少.
在冠状动脉样硬化中,单独和与WSS一起研究MWS.

研究的目的:

调查MWS与人类冠状动脉动脉样硬化的相关性,独立地和与WSS结合.
了解MWS在动脉样硬化斑块开始和进展中的作用.
为了将生物力学因素与冠状动脉壁厚度变化和富含脂质的死核核大小相关联.

主要方法:

在12个月内使用NIRS-IVUS和OCT对34个人类冠状动脉进行分析.
计算建模用于计算基线WSS和MWS.
线性混合模型用于评估生物力学因素与不同冠状动脉段壁厚度 (ΔWT) 和脂质丰富死核大小 (ΔLRNC) 的变化之间的关联.

主要成果:

较高的MWS与无斑块部门的血管壁生长增加相关.
在板块部门,更高的WSS和MWS (单独和组合) 与更大的墙壁厚度减少有关.
低MWS和高WSS的部门显示,脂质丰富的死核核大小的最大增加.

结论:

两种MWS和WSS都与冠状动脉样硬化的发病和发展有显著的关联.
在动脉样硬化的病理生理学中,MWS起着至关重要的,但经常被忽视的作用.
MWS和WSS之间的相互作用影响了斑块的组成和进展.

关键词:

动脉样硬化是一种动脉样硬化.一个冠状动脉.机械应力机械应力在 NIRS-IVUS 和 OCT 中.剪切压力压力是什么

更多相关视频

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Published on: December 6, 2024

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Published on: January 13, 2012

相关概念视频

Thin-Walled Hollow Shafts

Thin-Walled Hollow Shafts

In analyzing a thin-walled hollow shaft subjected to torsional loading, a segment with width dx is isolated for examination. Despite its equilibrium state, this segment faces torsional shearing forces at its ends. These forces are quantitatively described by the product of the longitudinal shearing stress on the segment's minor surface and the area of this surface, leading to the concept of shear flow. This shear flow is consistent throughout the structure, indicating a uniform distribution...