行为障碍 - - 对共患病模式,遗传和环境风险因素的全面探索
Natalia Tesli1, Piotr Jaholkowski2, Unn K Haukvik1
1Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo & Oslo University Hospital, Oslo, Norway; Centre of Research and Education in Forensic Psychiatry, Oslo University Hospital, Oslo, Norway.
Psychiatry research
|November 29, 2023
概括
年轻人的行为障碍 (CD) 与各种成人心理健康状况有关,共享遗传风险和基因环境相互作用. 这凸显了理解CD的重要性.
科学领域:
- 儿童和青少年精神病学
- 行为遗传学 行为遗传学
- 发展心理学 发展心理学
背景情况:
- 行为障碍 (CD) 是一种普遍存在的儿童精神障碍,其特征是反社会行为.
- 疾病可能是成人发病精神障碍的先发症,这表明诊断连续性和共同的遗传因素.
- 关于CD和成人精神障碍之间的遗传责任和基因环境相互作用的知识有限.
研究的目的:
- 在大型队列中调查CD与其他精神障碍的并发症.
- 检查心理健康特征和CD多基因风险得分 (PRS) 之间的关联.
- 在CD中探索基因环境相互作用,使用关于欺凌和家长教育的数据.
主要方法:
- 挪威母亲,父亲和儿童队列研究 (n=114,500) 的分析.
- 对CD与其他精神疾病之间的并发症的质疑.
- 心理健康特征与CD/CD特征的PRS关联分析.
- 使用欺凌和家长教育数据探索基因环境相互作用.
主要成果:
- 在CD和多种儿童和成人发病精神障碍之间发现了显著的共患性.
- 现型重叠对应于精神障碍和CD的PRS之间的显著关联.
- 这些发现支持对CD.的附加基因环境模型.
- 疾病与几种儿童和成人发病精神障碍的多基因风险有关.
结论:
- 行为障碍与一系列精神疾病具有显著的共患性.
- 其他精神疾病的遗传责任与CD相关,反映了共同的遗传基础.
- 研究结果强调需要在研究,诊断和临床后续中考虑CD的异质性.
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