多发性硬化症和衰老对神经肌肉功能的联合有害影响
Tobias Gaemelke1, Marie-Louise K Jørgensen1, Morten Riemenschneider1
1Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Experimental gerontology
|November 29, 2023
概括
患有多发性硬化症 (MS) 的老年人经历的神经肌肉衰退比健康个体更大,特别是在肌肉强度和力量发展方面. 这种下降在所有年龄组中都是明显的,在MS患者中,显著的差异较早出现.
科学领域:
- 神经学 神经学
- 老年学是指老年学的学科.
- 运动医学 运动医学
背景情况:
- 患有多发性硬化症 (MS) 的老龄化人口正在增长,由于MS和老龄化对神经肌肉功能的综合影响,这带来了独特的挑战.
- 多发性硬化和自然衰老过程独立地导致神经肌肉能力下降.
研究的目的:
- 为了在三个不同的年龄段 (年轻人,中年人和老年人) 中比较患有多发性硬化症 (pwMS) 和健康对照人群 (HC) 之间的神经肌肉功能.
- 在pwMS和HC中研究肌肉强度和激活模式的年龄相关差异.
主要方法:
- 采用横截面研究设计来评估神经肌肉参数.
- 用异动力学测量测量了膝盖伸缩器 (KE) 和脚部屈曲器 (PF) 的最大肌肉力量 (Fmax) 和力量发展率 (RFD).
- 自愿激活 (VA) 和静止抽 (RT) 使用插曲抽技术进行了评估.
主要成果:
- 与HC相比,MS患者在KE中表现出降低的Fmax,RFD和VA.在所有年龄组中,与HC相比,MS患者表现出降低的Fmax,RFD和VA.
- PF Fmax,RFD和RT的降低在中年和老年 pwMS 中更为明显.
- 与年龄相关的衰退轨迹有所不同,pwMS在KE中表现出较早的功能恶化 (年轻到中年) 与HC (中年到老年) 相比.
结论:
- 多发性硬化和衰老的协同作用显著损害神经肌肉功能,特别是在PF和KE中,在pwMS中显著的RFD缺陷.
- 虽然减少了VA和RT的贡献,但对神经调节的进一步研究是必要的,以充分阐明pwMS中观察到的大量RFD缺陷.
- 这些发现突显了老龄化pwMS中神经肌肉衰退的加速,并强调了针对性干预的必要性.
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