来自Geum japonicum var. 的心脏保护性多. 在中国,中国人
Tong Wu1, Fangbo Zhang1, Qingqing Cai2
1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Phytochemistry
|November 29, 2023
概括
从Geum japonicum中分离出7种新的日和一种脱基酸衍生物. 一些化合物,特别是众所周知的16和21,对H9c2细胞的氧化损伤表现出显著的心脏保护作用.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 心血管研究研究心血管研究
背景情况:
- 日本种 (Geum japonicum var.) 是一种植物. 是一种生物活性化合物的植物来源.
- 聚和素以其多样化的生物活动而闻名.
- 氧化应激在心血管疾病中起着至关重要的作用.
研究的目的:
- 从Geum japonicum var.中分离和表征新的和已知的多化合物. 中国人.中国人.
- 评估这些孤立化合物的心脏保护潜力,以防止H9c2大鼠心肌细胞中过氧化诱导的氧化损伤.
主要方法:
- 用95%的乙醇提取物从天线部件中分离化合物.
- 通过全面的光谱分析 (UV,IR,NMR,HRMS,CD) 阐明结构.
- 使用暴露于过氧化 (H2O2) 的H9c2细胞进行心脏保护活性体外评估.
主要成果:
- 发现了7种新型的素 (gejaponin A-G) 和一种脱基甲酸衍生物,以及18种已知的多.
- 测试了16种主要化合物的生物活性.
- 已知化合物16和21表明对H2O2诱导的H9c2细胞损伤有显著的保护作用.
- 化合物16和21的心脏保护活性与阳性对照剂trimetazidine相似.
结论:
- 日本种 (Geum japonicum var.) 是一种植物. 是一种丰富的结构多样化的多的来源.
- 化合物16和21表现出显著的心脏保护性质,表明对心血管疾病的治疗潜力.
- 需要进一步研究心脏保护作用背后的机制.
关键词:
心肌细胞氧化损伤是心肌细胞氧化损伤日本 (Geum japonicum Thunb.) 是一种天然的植物. 这里是 Var. Var. 的位置. 中国人F.波尔勒 (F.Bolle) 是一个聚醇是一种多醇.罗莎植物 (Rosaceae) 是一个植物.色素 (tannin) 是一种色素.更多相关视频
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