动态功能连接的改变时间性质与双相情感障碍中自杀企图相关
Huan Wang1, Rongxin Zhu2, Zhongpeng Dai3
1School of Computer Science and Artificial Intelligence, Changzhou University, Changzhou 213164, China.
Progress in neuro-psychopharmacology & biological psychiatry
|November 29, 2023
概括
试图自杀的双相情感障碍 (BD) 患者表现出不同的动态功能连接 (FC) 模式. 这些大脑连接的变化,特别是特定网络中的变化,可以作为自杀风险评估的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 双极性障碍 (BD) 在精神疾病中具有最高的自杀风险.
- 在BD中自杀企图 (SA) 的神经生物学基础尚未完全理解.
研究的目的:
- 研究BD患者的动态功能连接 (FC) 异常和SA之间的关系.
- 探索动态FC的时间性质及其与临床变量的相关性.
主要方法:
- 休息状态功能性MRI数据使用滑动窗口方法进行分析.
- 在114名BD患者 (50名SA,64名无SA) 和81名健康对照 (HC) 中评估了动态FC模式.
- 研究了动态FC和网络连接变化的时间性质.
主要成果:
- 一个特定的大脑功能状态与SA显著相关.
- 在这种状态下,SA患者的时间动态发生了变化 (分数窗口增加,停留时间,状态过渡).
- 在自杀相关状态期间,在SA患者中观察到皮下 (SubC-SubC),默认模式 (DMN-SubC) 和注意力 (AN-SubC) 网络中的改变FC.
- 这些改变的指标与自杀风险有显著的相关性.
结论:
- 在SubC-SubC,DMN-SubC和AN-SubC网络中的受损动态FC与BD中的SA有关.
- 全脑动态FC的时间性质可以作为自杀风险评估的生物标志物.
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