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基于鱼油的微乳液可以有效地提供阻断PD-1/PD-L1的口服,并同时诱导癌症免疫疗法的铁亡

Xin Yang¹, Wanqiong Li¹, Shuzhen Li¹

¹School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.

Journal of controlled release : official journal of the Controlled Release Society

|November 29, 2023

概括

一种新的鱼油微乳液有效地通过口服提供类免疫检查点抑制剂. 这种方法通过促进T细胞透和诱导癌细胞中的铁亡来增强生物可用性和抗瘤免疫力.

科学领域:

制药科学制药科学
纳米技术纳米技术
癌症免疫疗法癌症免疫疗法

背景情况:

由于稳定性和透性差,口服类药物的输送具有挑战性.
类免疫检查点抑制剂在癌症免疫治疗中表现有前途,但面临着交付障碍.

研究的目的:

开发一种基于鱼油的微乳液,用于口服输送类免疫检查点抑制剂 (OPBP-1).
评估开发的配方的稳定性,生物可用性和抗瘤功效.

主要方法:

在没有辅助表面活性剂的鱼油基微乳液的配方.
粒子大小,药物释放和稳定性的表征.
使用Caco-2细胞用于药物吸收的体外研究.
在小鼠结肠癌模型中的体内研究 (CT26).

主要成果:

微乳液在肠道环境中表现出极好的稳定性和持续的药物释放.
观察到肠道吸收的增强和口服生物可用性的4.1倍增加.
在体内研究显示CD8+ T淋巴细胞透增加,干扰素-γ分泌和显著的瘤生长抑制.
鱼油通过诱导铁亡来显示出协同作用的抗瘤作用.

结论:

基于鱼油的微乳液是癌症免疫治疗中口服递送的有前途的系统.
该配方利用天然特性来增强药物输送和协同作用的抗瘤作用.
这种方法为口腔基癌症疗法提供了一个绿色和有效的平台.

关键词:

结肠直肠癌是一种癌症.铁性化 (ferroptosis) 是一种鱼油鱼油是一种鱼油.这是一种口服.在PD-1/PD-L1中.癌症免疫疗法免疫疗法

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