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4073 基因型作为儿童急性淋巴细胞白血病的预后预测因子

Pei-Chen Hsu¹, Chao-Chun Chen¹, Ya-Chen Yang²

¹Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.

Anticancer research

|November 29, 2023

概括

介乐素8 (IL-8) rs4073多态性与女孩和年幼儿童急性淋巴细胞白血病 (ALL) 风险增加有关. 这种遗传标记也预测了儿童ALL患者的更高风险分类和更短的存活时间.

科学领域:

遗传学是一个遗传学.
儿科瘤学儿科瘤学
分子生物学分子生物学

背景情况:

介素8 (IL-8) 在耐火性急性淋巴细胞白血病 (ALL) 中表达高.
调查IL-8基因变异在儿童ALL敏感性中的作用至关重要.

研究的目的:

检查IL-8基因多态 (rs4073,rs2227306,rs2227543,rs1126647) 与儿童ALL风险之间的关联.
确定这些多形态是否与年龄和性别相互作用,从而影响ALL风险.

主要方法:

使用PCR-RFLP进行IL-8多态的基因组化 (rs4073,rs2227306,rs2227543,rs1126647).
病例控制研究涉及266个儿童ALL病例和266个对照.
基于年龄和性别的分层分析.

主要成果:

在ALL病例和对照之间,研究IL-8多态的总体基因型或等位基因频率没有显著差异.
IL-8 rs4073 AA基因型与女孩和3岁半以下儿童患儿ALL风险较高有关.
IL-8 rs4073 AT和AA基因型与儿童ALL的更高风险分类和更短的存活率相关.

结论:

IL-8 rs4073 A基因组可以作为特定子组 (女孩,年龄≤3.5岁) 儿童ALL的诊断预测因子.
IL-8 rs4073多态性是高风险分类和儿童ALL生存率降低的显著预后标志物.
建议进行进一步的验证研究,以将这种预后标志物纳入临床实践.

关键词:

儿童的急性淋巴细胞白血病.基因型基因型基因型介质蛋白-8-8的使用方法多形态主义的多态主义.

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