器官特异性瘤对Avelumab维持治疗的反应 晚期泌尿腺癌:一个多中心回顾性研究
Nobuki Furubayashi1, Akinori Minato2, Toshihisa Tomoda3
1Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan; nobumduro@gmail.com.
Anticancer research
|November 29, 2023
概括
在晚期泌尿腺癌中,AVELUMAB维持疗法显示出各种各样的器官特异性反应. 然而,总体存活率根据转移部位并没有显著差异,这表明了阿维卢马布的存在.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 尿癌研究 尿癌研究
背景情况:
- 在晚期泌尿腺癌 (UC) 维持治疗中,阿维卢马布的器官特异性疗效尚不清楚.
- 了解这些影响对于优化治疗策略至关重要.
研究的目的:
- 评估AVELUMAB在晚期泌尿腺癌的维持疗法的器官特异性治疗效果.
- 根据器官参与来评估无进展生存率 (PFS) 和总生存率 (OS).
主要方法:
- 在一线化疗后,对42名晚期UC患者进行了回顾性分析,这些患者在一线化疗后接受了avelumab治疗.
- 对器官特异性反应率,PFS和OS的评估.
- 用于比较基于器官转移的生存结果的日志级别测试.
主要成果:
- 总体应答率为2.4%,疾病控制率为47.6%.
- 根据原发性瘤器官疾病和肝脏转移,观察到PFS的显著差异.
- 在各种转移器官中,没有发现整体存活率 (OS) 的显著差异.
结论:
- 在晚期UC中,Avelumab维持疗法显示出不同的器官特异性反应.
- 尽管反应不同,但阿维卢马布并没有显著影响总体存活率,这取决于任何特定器官中转移的存在或不存在.
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