限制性与标准流体管理在机械通风儿童录入PICU:试点随机对照试验 (REDUCE-1) 的研究协议
Sainath Raman1,2, Sarfaraz Rahiman2,3, Melanie Kennedy4
1Children's Intensive Care Research Program, Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia sainath.raman@uq.edu.au.
这项研究评估了限制性流体策略与重症儿童的标准方法. 它发现,限制性流体策略对于儿科重症监护患者来说是可行的和安全的.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 液体复苏器 液体复苏器
- 儿童的功能 儿童的功能
背景情况:
- 静脉注射液疗法是重症儿童的常见干预措施.
- 有证据表明,大量的液体可能是不安全的.
- 最佳的流体管理策略仍然不清楚.
研究的目的:
- 测试一个务实的随机对照试验的可行性.
- 为了比较重症儿童的限制性与标准 (自由) 流体管理.
主要方法:
- 一个多中心,双国试点随机对照试验.
- 在儿科重症监护病房中,有154名机械通风儿童 (<18岁) 被随机分为1:1组.
- 干预涉及限制性液体捆绑48小时或直到放电.
主要成果:
- 可行性终点包括患者招募率.
- 安全性终点包括新发急性损伤和中央静脉血栓症.
- 评估的疗效和临床终点是流体平衡和存活率.
结论:
- 在重症儿童中,限制流体的策略是可行的.
- 需要进一步的研究来确定最佳的流体管理.
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