益生菌 巴西菌种类. 增强巨细胞中TLR3介导的TNF信号传递
Katrine Damgaard Winther1,2, Erik Juncker Boll1, Dorthe Sandvang1
1Chr. Hansen A/S, Animal and Plant Health & Nutrition, Hørsholm, Denmark.
Immunology
|November 29, 2023
概括
益生菌细菌菌株可以通过调节巨细胞功能来增强免疫反应. 某些细菌菌株在增强对病毒感染的先天免疫力方面表现有前途,提供潜在的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 益生菌具有免疫调节作用,但机制尚不清楚.
- 了解益生菌与宿主相互作用对于传染病和炎症管理至关重要.
研究的目的:
- 研究特定的益生菌细菌菌株如何调节巨细胞的功能.
- 阐明在病毒感染期间益生菌诱导的免疫反应背后的机制.模仿病毒感染.
主要方法:
- 在RAW 264.7巨细胞中选了14种益生菌菌株进行细胞因子调节,这些巨细胞被用聚I:C刺激.
- 分析了使用初级猪膜巨细胞的七个选定菌株.
- 对两个关键菌株的膜巨进行了转录基因分析.
主要成果:
- 大多数菌株在RAW 264.7细胞中协同增加了INTERLEUKIN-6 (IL-6) 和瘤坏死因子-alpha (TNF-α) 的分泌与多I:C.
- 这种协同效应与收费类受体2 (TLR2) 独立.
- 只有Bacillus spp. 才能使用. 诱导了膜巨细胞的这种效应,与TNF和IL23A通路的上调相关.
结论:
- 益生菌细菌具有取决于菌株的免疫调节特性.
- 细菌菌株可以增强天生的免疫反应,特别是对抗病毒挑战.
- 研究结果表明,益生菌有助于增强宿主防御机制的潜力.
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